During the thirteen years of publication of Druuna’s adventures in Morbus Gravis, the plot has evolved through several stages, differentiated with numerous jumps in the storyline, with some attendant inconsistencies. In the first volumes in the series, the action unfolds is a place called The City, a futuristic but degraded urban environment. Humans live in a cramped, hostile, and decadent society, controlled by a religious oligarchy based on the knowledge of “Truth.” In this society, books are banned and power is exercised by a corrupt and despotic militarized bureaucracy. Although never clearly stated, this current era, known as the “Age of Man”, is presumed to be the aftermath of a kind of war. As told by the priests, Evil had been visited on the populace by an incurable, infectious disease that transforms people in a progressive and rapid fashion into amorphous, tentacled mutants. As a precautionary measure, all of the City’s inhabitants are forcibly injected with a serum periodically distributed in overcrowded health facilities. Many believe that those found to be “healthy” will be sent to the City’s upper levels, a place inaccessible to the majority but where those selected enjoy a better life free from want and hardship. Similarly, those infected with “Evil” are sent to the lower levels. Druuna and her lover Shastar exist in this environment. After a series of adventures, Druuna discover that the City is actually a giant spaceship which left Earth after an unspecified cataclysm and has drifted through space for centuries. At some point, Lewis, the ship’s captain, delegated control to the computer Delta, which is responsible for creating the current state of affairs. (The Priests are actually androids operated by Delta.) Delta transformed Lewis into an immortal being, using organic parts from the healthy people who had been admitted to the upper levels of the City.